South San Francisco Homes for Sale
36 Homes for sale in South San Francisco
$1,478,000
343 Alta Mesa Drive
South San Francisco, CA 94080
$1,098,000
3700 Brunswick Court
South San Francisco, CA 94080
$1,248,000
643 Grand Avenue
South San Francisco, CA 94080
$924,800
1 Mandalay Place #1510
South San Francisco, CA 94080
$1,798,000
7222 Shannon Park Court
South San Francisco, CA 94080
$929,888
1400 El Camino Real #220
South San Francisco, CA 94080
$2,099,000
23 Shasta Court
South San Francisco, CA 94080
$1,598,000
2200 Delvin Way
South San Francisco, CA 94080
$1,200,000
107 Mulberry Avenue
South San Francisco, CA 94080
$1,299,888
227 Rockwood Drive
South San Francisco, CA 94080
$975,000
523 Baden Avenue
South San Francisco, CA 94080
$559,888
3550 Carter #11
South San Francisco, CA 94080
$1,749,000
770 Miller Avenue
South San Francisco, CA 94080
$1,385,000
889 McLellan Drive #210
South San Francisco, CA 94080
Browse South San Francisco by Property Type
South San Francisco Neighborhood Guide
South San Francisco — "The Industrial City" as its famous hillside sign proclaims — has transformed from its blue-collar roots into a thriving biotech hub while maintaining its affordable, family-friendly residential neighborhoods. Located just south of San Francisco and minutes from SFO airport, South City offers one of the best value propositions on the Peninsula.
Why Buyers Love South San Francisco
- Peninsula value — Among the most affordable cities on the Peninsula, with median prices significantly below neighbors like San Mateo and Burlingame.
- Biotech jobs — The city is home to Genentech and hundreds of biotech companies along Oyster Point Boulevard, creating strong local employment.
- BART + Caltrain — Two BART stations (South San Francisco and San Bruno) plus a Caltrain station make this one of the best-connected Peninsula cities.
- Close to everything — 10 minutes to SFO, 20 minutes to downtown SF, 30 minutes to Silicon Valley.
Neighborhoods at a Glance
Westborough
The most desirable residential area with hillside homes, views, and proximity to Westborough Middle School. Popular with families.
Sign Hill
Named for the iconic hillside letters. Older homes on hills with views of the bay. Active neighborhood association.
Downtown/Grand Avenue
The city's historic core with local restaurants, shops, and the recently renovated Grand Avenue. Walkable and transit-accessible.
Sunshine Gardens
Established residential neighborhood with mid-century single-family homes. Good value for the Peninsula.
Oyster Point
Near the biotech corridor and waterfront. Newer condo and townhome developments. Walk-to-work for Genentech employees.
Local Amenities
Parks
Sign Hill Park (hiking with panoramic views), Orange Memorial Park, Oyster Point Marina
Shopping
Tanforan (The Shops at Tanforan), Grand Avenue shops, nearby Serramonte Center
Dining
Grand Avenue restaurants, Oyster Point waterfront dining, diverse cuisines reflecting the city's multicultural population
Recreation
Orange Memorial Park pool and recreation center, Sign Hill hiking, Oyster Point Marina kayaking and paddleboarding
Commute Times
| Destination | Drive | Transit |
|---|---|---|
| San Francisco (Downtown) | 15-25 min | 20 min (BART) |
| SFO Airport | 5-10 min | 8 min (BART) |
| Daly City | 10-15 min | 10 min (BART) |
| San Mateo | 10-15 min | 10 min (Caltrain) |
| Silicon Valley (Palo Alto) | 25-35 min | 35 min (Caltrain) |
South San Francisco's dual BART and Caltrain access makes it a transit sweet spot on the Peninsula — ideal for commuters heading both north to SF and south to Silicon Valley.
Commute times are estimates and may vary based on traffic, time of day, and route. Data is for informational purposes only.